Light‐Controlled Nanosystem with Size‐Flexibility Improves Targeted Retention for Tumor Suppression

Although great promise has been achieved with nanomedicines in cancer therapy, limitations are still encountered, such as short retention time the tumor. Herein, a nanosystem that can modulate particle size situ by near-infrared (NIR) light is self-assembled cross-linking surface-modified poly(lactic-co-glycolic acid) from up-conversion nanoparticle indocyanine green and doxorubicin–nitrobenezene–polyethylene glycol (DOX–NB–PEG). The its small (≈100 nm) achieves better tumor targeting, while PEG on surface of effectively shield adsorption proteins during blood circulation, maintaining stable nanostructure achieving good targeting. Moreover, at realizes rapid shedding NIR irradiation, enhanced cellular uptake. At same time, aggregation occurs inside to form bigger particles (≈600 situ, prolonging producing targeted therapeutic effects. In vitro data show higher uptake rate apoptosis after vivo prove have longer residence site irradiation. This demonstrates an effective strategy synergistic tumors.